Abstract
Component-resolved diagnosis (CRD), enables the identification of genuine and cross-reactive allergen molecules. The aim of this study was to compare the results of the skin prick test (SPT), specific immunoglobulin E (sIgE), and CRD in–birch-pollen sensitive preschool children. The subjects’ mothers answered a standardized questionnaire about clinical manifestations after peanut ingestion by their children. The sIgEs were determined by the fluorescence enzyme immunoassay, and CRD by microarray technique. Children with birch-positive/peanut-positive SPT developed generalized urticaria or oral allergy syndrome within 30 minutes after ingesting peanuts. Discordant results between peanut-SPT and peanut-sIgE, and between peanut-sIgE and peanut-genuine-CRD, respectively, were confirmend. The results of CRD distinguished genuine from cross-reactive allergens. The SPT and sIgE may detect sensitization and cosensitization to allergen extracts, and CRD may detect sensitization and cosensitization to genuine and cross-reactive allergen components in preschool children. Further investigations are required to ascertain the causes of discordant results.
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