Abstract
GENTAMICIN was isolated from members of the genus Micromonospora by Weinstein et al. (1963). This antibiotic was found effective in vitro against several species of Gram negative bacteria (Bulgar et al., 1963; Rubenis et al., 1964; Jao and Jackson, 1964). Gentamicin was subsequently found to be highly efficacious in vivo against species of Gram negative bacteria causing urinary tract infections in man (Jao and Jackson, 1964; Klein et al., 1964; Cox and Garvey, 1967; and Lipton, 1967).Tests conducted in this laboratory by a method similar to that outlined by Tierno (1969), indicated that each of two isolates of Arizona 7:1,7,8 was inhibited in vitro by a gentamicin concentration between 0.625 and 1.25 micrograms per milliliter. Subsequently, a study was undertaken to determine the efficacy of gentamicin against artificially induced Arizona 7:1,7,8 infection in young turkeys. The manifestations of the “paracolon” infection have been described by Bruner and Peckham (1952),…
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