Abstract
THE NEW, broad-spectrum antiobiotic, gentamicin sulfate, is of particular interest in the treatment of eye infections. It is active against common staphylococci and streptococci,<sup>1,2</sup><i>Diplococcus pneumoniae, Haemophilus influenzae</i>,<sup>3</sup>and numerous species of gram-negative bacteria<sup>1-3</sup>including<i>Pseudomonas aeruginosa</i>. In vivo, gentamicin protected rabbit eyes against destruction from experimentally induced pseudomonal infection.<sup>4</sup>In one report of clinical use in eye infections,<sup>5</sup>a few patients were treated successfully with gentamicin sulfate ophthalmic preparation for infection with<i>Moraxella</i>(diplobacillus of Morax-Axenfeld),<i>Neisseria gonorrhoeae</i>(gonococcus), and<i>Haemophilus aegyptius</i>(Koch-Weeks bacillus). To study 0.3% gentamicin sulfate ophthalmic drops or ointment in eye infections, we treated 131 patients: 53 with the ointment, 72 with the drops, and 6 with both. Most (118) were treated for one week or less; 11 were treated for 8 to 13 days, and 2 for 20 to 30 days. Concurrent therapy included hot and cold compresses, atropine
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