Abstract
BackgroundAround about 1970, a gentamicin-loaded poly (methylmethacrylate) (PMMA) bone cement brand (Refobacin Palacos R) was introduced to control infection in joint arthroplasties. In 2005, this brand was replaced by two gentamicin-loaded follow-up brands, Refobacin Bone Cement R and Palacos R + G. In addition, another gentamicin-loaded cement brand, SmartSet GHV, was introduced in Europe in 2003. In the present study, we investigated differences in gentamicin release and the antibacterial efficacy of the eluent between these four cement brands.Methods200 μm-wide gaps were made in samples of each cement and filled with buffer in order to measure the gentamicin release. Release kinetics were related to bone cement powder particle characteristics and wettabilities of the cement surfaces. Gaps were also inoculated with bacteria isolated from infected prostheses for 24 h and their survival determined. Gentamicin release and bacterial survival were statistically analysed using the Student's t-test.ResultsAll three Palacos variants showed equal burst releases but each of the successor Palacos cements showed significantly higher sustained releases. SmartSet GHV showed a significantly higher burst release, while its sustained release was comparable with original Palacos. A gentamicin-sensitive bacterium did not survive in the high gentamicin concentrations in the interfacial gaps, while a gentamicin-resistant strain did, regardless of the type of cement used. Survival was independent of the level of burst release by the bone cement.ConclusionsAlthough marketed as the original gentamicin-loaded Palacos cement, orthopaedic surgeons should be aware that the successor cements do not appear to have the same release characteristics as the original one. Overall, high gentamicin concentrations were reached inside our prosthesis-related interfacial gap model. These concentrations may be expected to effectively decontaminate the prosthesis-related interfacial gap directly after implantation, provided that these bacteria are sensitive for gentamicin.
Highlights
Around about 1970, a gentamicin-loaded poly (PMMA) bone cement brand (Refobacin Palacos R) was introduced to control infection in joint arthroplasties
Bone cements Four commercially-available gentamicin-loaded PMMA bone cement brands were used in this study: Refobacin Palacos R (Biomet Merck/Biomet Europe, Germany), Refobacin Bone Cement R (Biomet Europe, Germany), Palacos R + G (Heraeus Medical GmbH, Germany), and SmartSet GHV (DePuy CMW, England)
Conclusions marketed as the original Refobacin Palacos R, orthopaedic surgeons should be aware that the successor cements (Refobacin Bone Cement R and Palacos R + G) do not appear to have the same release characteristics as the original cement
Summary
Around about 1970, a gentamicin-loaded poly (methylmethacrylate) (PMMA) bone cement brand (Refobacin Palacos R) was introduced to control infection in joint arthroplasties. In 2005, this brand was replaced by two gentamicin-loaded follow-up brands, Refobacin Bone Cement R and Palacos R + G Another gentamicin-loaded cement brand, SmartSet GHV, was introduced in Europe in 2003. The two companies filled this blank with follow-up products: Refobacin Bone Cement R (distributed by Biomet Europe) and Palacos R + G (distributed by Heraeus GmbH). Both companies claim that the new cements are equivalent to their predecessor. The antibacterial efficacy of an ALBC is not entirely determined by the kinetics of release of the antibiotic [8]
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