Gentamicin pharmacokinetics and pharmacodynamic correlation in pediatrics—A systematic review

Keerthana Chandrasekar,Shalini R,Arun Kp,Vijay V,Vahini B

doi:10.7324/japs.2021.1101102

Abstract

Study of Renal enzymuria and albuminuria activity in the Petals of Pink Nelumbo nucifera Gaertn.R. V. Saraswathi, F. Gricilda Shoba

Highlights

When there is a seasonal change, the prevalence of respiratory infections is high in children
Gentamicin is a narrow therapeutic index drug belonging to the class of aminoglycosides which is effective against Gram-negative organisms such as Escherichia coli, Klebsiella species, Pseudomonas aeruginosa, Klebsiella pneumonia, and Staphylococcus aureus, and resistant against Enterobacteriaceae, Enterococci, and Staphylococci (Krause et al, 2016; Lundergan et al, 1999; MacDougall and Chambers, 2011)
Pharmacokinetic approach in different disease conditions In Gram-negative bacterial infections, pediatric patients receiving a dose of 7.5 mg/kg/day of gentamicin as the drug of choice

Summary

Introduction

When there is a seasonal change, the prevalence of respiratory infections is high in children. Gentamicin is a narrow therapeutic index drug belonging to the class of aminoglycosides which is effective against Gram-negative organisms such as Escherichia coli, Klebsiella species, Pseudomonas aeruginosa, Klebsiella pneumonia, and Staphylococcus aureus, and resistant against Enterobacteriaceae, Enterococci, and Staphylococci (Krause et al, 2016; Lundergan et al, 1999; MacDougall and Chambers, 2011). It is mainly indicated for the treatment of both upper and lower respiratory tract infections, urinary tract infections (UTI), meningitis, bacterial neonatal sepsis, peritonitis, bacterial septicemia, skin, bone, and soft tissue infections (Pacifici, 2015).

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