Abstract
Background. Gentamicin (GM) induced nephrotoxicity may be sex hormones related. The effects of sex hormones on GM induced nephrotoxicity in gonadectomized rats were investigated. Methods. Ovariectomized rats received 0.25, 0.5, or 1 mg/kg/week of estradiol (ES) alone or accompanied with 10 mg/kg/week of progesterone (Pro) for two weeks followed by GM (100 mg/kg/day) for 9 days. Castrated rats were also treated with 10, 50, or 100 mg/kg/week of testosterone (TS) for two weeks and then received GM. In addition, a single castrated group received 0.25 mg/kg/week of ES plus GM. Results. GM increased the serum levels of blood urea nitrogen (BUN) and creatinine (Cr) and kidney tissue damage score (KTDS) (P < 0.05). TS had no effect on the serum levels of BUN and Cr and KTDS, while low dose of ES intensified these parameters in male (P < 0.05). ES (0.5 mg/kg) without Pro ameliorated KTDS in female (P < 0.05) while ES (1 mg/kg) with or without Pro exacerbated the BUN values and Cr values, KTDS, and body weight loss (P < 0.05). Conclusion. ES (0.5 mg/kg) without Pro ameliorated kidney damage induced by GM in female while neither TS nor ES had beneficial effect on nephrotoxicity induced by GM in male, although ES aggravated it.
Highlights
Gentamicin (GM) is one of the aminoglycoside drugs which is commonly used for treatment of negative gram bacterial infections [1, 2]
The most important side effect of this drug is nephrotoxicity [3] which is accompanied with elevating blood urea nitrogen (BUN) and creatinine (Cr) levels in serum [4, 5]
ES (1 mg/kg) administration increased the levels of BUN and Cr in comparison with GM alone and ES (0.5 mg/kg) plus GM treated groups, Table 2: The effect of gentamicin (GM) on the serum levels of blood urea nitrogen (BUN), creatinine (Cr), malondialdehyde (MDA), kidney level of MDA, kidney tissue damage score (KTDS), body weight change (ΔBW), kidney weight (KW), and uterus weight (UW) in male and female rats
Summary
Gentamicin (GM) is one of the aminoglycoside drugs which is commonly used for treatment of negative gram bacterial infections [1, 2]. The most important side effect of this drug is nephrotoxicity [3] which is accompanied with elevating blood urea nitrogen (BUN) and creatinine (Cr) levels in serum [4, 5]. Some studies showed the impact of gender in cisplatin induced nephrotoxicity model [11,12,13,14,15] while GM induced gender related difference in some biomarkers [16]. It seems that sex hormones play an important role in GM induced nephrotoxicity. ES (0.5 mg/kg) without Pro ameliorated kidney damage induced by GM in female while neither TS nor ES had beneficial effect on nephrotoxicity induced by GM in male, ES aggravated it
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