Abstract
Genotyping of Lipoprotein(a) Gene Variants in Coronary Artery Disease in Indian Population
Highlights
India is undergoing an epidemiological transition and an alarming rise in the prevalence of coronary artery disease (CAD)
Lp(a) is a plasma lipoprotein consisting of a cholesterol-rich LDL-like particle, having apolipoprotein(a) attached to apo B via a disulfide bond.[8]
The basic LDL component has a lipid core formed by cholesteryl esters and triglycerides, which is surrounded by a layer of unesterified cholesterol, phospholipids, and an apolipoprotein B-100 molecule
Summary
India is undergoing an epidemiological transition and an alarming rise in the prevalence of coronary artery disease (CAD). In the quest for non-traditional risk factors, we found that Lipoprotein(a) gene and its product are unique and pertinent to the Indian population. To unravel the genetic blueprint of the variations within the LPA gene in Indians, we studied novel exonic and intronic SNPs in 60 patients with angiographically proven CAD and matched them with healthy volunteers. We observed that in our patients, LPA aspirin genotype rs3798220 did not cause variation in Lp(a) levels in either of the two groups which is a novel finding as it is at odds with most published studies from other populations, on this variant. The non-traditional risk factors have proved to bridge this gap to an extent, together with the fact that CAD being highly heritable, bringing to light the complex polygenic backdrop of the setting of the disease. The apo “a” particle surrounds this complex and is attached by a disulfide bond to the apo B-100 component as shown in Source of support: Indian Council of Medical Research (ICMR) under grant for MD/MS/MCh/DM Thesis (2015)
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