Abstract
Human papilloma virus (HPV) infection is a causative factor for cervical cancer. Early detectionrisk HPV types might help to identify women at high risk of cervical cancer. The aim of of highHPV infection in population of rgir hgih determine the occurrence of the present study was toIraqi women in Baghdad by using Multiplex PCR determine the percentage and genotyping ofHuman Papilloma Virus and to put the best prevention and control program in Iraqi women.Study started at January 2009 to March 2010, cervical samples were collected from 856 womenaged 16–70. HPV DNA amplification was performed using HPV High Risk Typing PCR Kit testfor qualitative detection and genotyping of HPV types 16, 18, 31, 33, 35, 39, 45, 52, 56, 58, 59, 66 inHPV was detected in 106 ( 12,38% ) of the study population, with a range of the cervical swabs.16-70 years age groups. Results showed that the overall HPV prevalence twelve genotypes wereidentified, including HPV-33 (18.60%), HPV-35 (18.60%), HPV-56 (18.60%) ,HPV-39(10.85%),HPV-52 (10.08%), HPV-18 (7.75%), HPV-16 (4.65%), HPV-59 (4.65%), HPV-58(2.32%), HPV-31(1.55%), HPV-45(1.55% ) and HPV-66( 0.77%). Of 856, 218 women was also tested by pap smearith normal cytology was 198 ( 90.83%), 24(12.12%) of them were HPV positive, those with w,abnormal cytology was 20 (9.17 %), 5( 25%)of them was HPV positive. In this study unlike otherepidemiological studies, HPV33,35,56 was the most frequent type (55.8%) in Baghdad, followedby HPV39, HPV52, HPV18, HPV16.
Highlights
Human papillomavirus (HPV) infection has a central role in the etiology of cervical cancer [1]
Our results show that the overall HPV prevalence twelve genotypes were identified, including HPV-33 (18.60%), HPV-35 (18.60%), HPV-56 (18.60%),HPV-39(10.85%), HPV-52 (10.08%), HPV-18 (7.75%), HPV-16 (4.65%), HPV-59 (4.65%), HPV-58(2.32%), HPV-31 (1.55%), HPV-45(1.55% ) and HPV-66( 0.77%) Figure(4)
Stoler [17] was reported that the incidence of cervical cancer in women under 25–30 years of age is extremely low, and the prevalence of HPV in the United States drops from approximately 40% at age to 10–20% at age 30– 40,this finding is concordant with this work were HPV prevalence was highest between and 30 years old and followed by age groups (31 to 40 years old) Figure (1,2)
Summary
Human papillomavirus (HPV) infection has a central role in the etiology of cervical cancer [1]. Women who are infected with high risk HPV type have an approximately 100-fold increased risk of developing cervical cancer than non infected women.
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