Abstract
Serologic and molecular surveillance of serum collected from 152 suspected scrub typhus patients in Myanmar revealed Orientia tsutsugamushi of genotypic heterogeneity. In addition, potential co-infection with severe fever with thrombocytopenia syndrome virus was observed in 5 (3.3%) patients. Both scrub typhus and severe fever with thrombocytopenia syndrome are endemic in Myanmar.
Highlights
Aye Marlar Win,1 Yen Thi Hai Nguyen,1 Yuri Kim,1 Na-Young Ha, Jun-Gu Kang, Hongil Kim, Bo San, Okkar Kyaw, Wah Win Htike, Dong-Ok Choi, Keun-Hwa Lee,2 Nam-Hyuk Cho2
Scrub typhus is a miteborne febrile illness caused by the bacterium Orientia tsutsugamushi, which is endemic in the Asia-Pacific region and a major cause of undifferentiated febrile disease [1]
No report has described the prevalence and genetics of scrub typhus in Myanmar, 2 studies, including 1 from 2017, identified scrub typhus as one of the primary infections causing acute febrile illness on the Thailand–Myanmar border [3,4]. These results underscore the need for research on this vectorborne infection in Myanmar, including studies defining the genotypic diversity of O. tsutsugamushi
Summary
Aye Marlar Win, Yen Thi Hai Nguyen, Yuri Kim, Na-Young Ha, Jun-Gu Kang, Hongil Kim, Bo San, Okkar Kyaw, Wah Win Htike, Dong-Ok Choi, Keun-Hwa Lee, Nam-Hyuk Cho. No report has described the prevalence and genetics of scrub typhus in Myanmar, 2 studies, including 1 from 2017, identified scrub typhus as one of the primary infections causing acute febrile illness on the Thailand–Myanmar border [3,4] These results underscore the need for research on this vectorborne infection in Myanmar, including studies defining the genotypic diversity of O. tsutsugamushi. We used blood samples from suspected scrub typhus patients in Myanmar to investigate the serologic prevalence and genotypic diversity of O. tsutsugamushi We examined these patients for possible co-infection with SFTSV, which has been an emerging threat to public health in eastern Asia. Mean fever duration was 6 days (SD ± 2.9 days)
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