Abstract
BackgroundThe genotypic diversity and cariogenicity of C. albicans from the dental plaque of children are poorly understood. This study aimed to explore the genotypic diversity and cariogenicity of C. albicans from children with early childhood caries and caries-free children.MethodsDental plaque samples from 238 children with early childhood caries and from 125 caries-free children were collected for C. albicans isolation. A PCR method based on 25S rDNA was used to analyze C. albicans genotypes, and the strains with different genotypes were tested with regard to acidogenicity and aciduricity.ResultsAmong 129 C. albicans isolates, 79 (61.2 %) belonged to genotype A. The distribution frequency of genotypes A and C or genotypes B and C showed no significant difference between children with early childhood caries and caries-free children (p = 0.178 and 0.148), whereas genotypes A and B exhibited significantly different distributions (p = 0.010). No significant differences in aciduricity were found among the three genotypes, but the acidogenicity of genotypes B and C differed significantly from that of genotype A at pH 4.0.ConclusionsThe genotypic distribution of C. albicans is associated with the caries experience of children, and the genotype may be related to its acidogenicity at pH 4.0.
Highlights
The genotypic diversity and cariogenicity of C. albicans from the dental plaque of children are poorly understood
C. albicans genotypic distribution C. albicans strains were isolated from 129 subjects (35.5 % of 363 children): 105 children with Early childhood caries (ECC) and 24 CF children
Genotypes A and B were distributed in a significantly different manner in the two groups (p = 0.010): genotype A presented a higher frequency in the CF group, and genotype B presented a higher frequency in the ECC group
Summary
The genotypic diversity and cariogenicity of C. albicans from the dental plaque of children are poorly understood. This study aimed to explore the genotypic diversity and cariogenicity of C. albicans from children with early childhood caries and caries-free children. C. albicans is often detected in children with dental caries, while this yeast is typically absent in caries-free children [2, 3]. These findings provide indirect evidence for the association of C. albicans with dental caries. The frequency of C. albicans isolated in dental plaque from children with ECC was confirmed to be higher than that in caries-free (CF) children (44.1 vs 19.2 %, χ2 = 22.213, p < 0.001), which indicated that C. albicans is related to ECC [4]
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