Genotypic association of exonic LGI4 polymorphisms and childhood absence epilepsy.

Wenli Gu,Ortrud K Steinlein,Thomas Sander,Tim Becker

doi:10.1007/s10048-003-0158-8

Genotypic association of exonic LGI4 polymorphisms and childhood absence epilepsy.

Wenli Gu, Ortrud K Steinlein + Show 2 more

https://doi.org/10.1007/s10048-003-0158-8

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Journal: neurogenetics	Publication Date: Sep 19, 2003
Citations: 33

Affiliation: University Hospital Bonn, Humboldt-Universität zu Berlin, Charité - Universitätsmedizin Berlin, Max Delbrück Center for Molecular Medicine, Institut für Medizinische Biometrie, Informatik und Epidemiologie, University of Bonn

#Benign Familial Infantile Convulsions #Childhood Absence Epilepsy + Show 8 more

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Abstract

The LGI4 gene is located in a region linked to benign familial infantile convulsions (BFIC) and idiopathic generalized epilepsy. Screening of the LGI4 coding region in BFIC and childhood absence epilepsy (CAE) revealed several frequent exonic polymorphisms. A genotypic association was found for the c.1914GC --> AT polymorphism in 42 CAE patients compared with 110 population controls (chi2 = 6.66, df = 1, P = 0.01), providing evidence for a so far undetected susceptibility allele for CAE in the LGI4 region.

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