Abstract
We have analyzed the phage yields of bacteria infected with two mutants of bacteriophage f1. The chromosomes of these mutants are unable to multiply in the host before the occurrence of a recombination event that generates a wild-type particle. As a result the genotypes found in the phage yields of individual cells consist exclusively of the products of this recombination event. The majority of the observed recombination events generate one recombinant genotype and one other genotype identical to that of either of the two parents, with respect to both selected and unselected markers. These results cannnot be reconciled with a reciprocal breakage-reunion model for recombination. Other models for recombination between DNA duplexes are discussed. We propose a breakage-copying model that accounts for our results and could also account for the general occurrence of both reciprocal and non-reciprocal recombination.
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