Genotype C/C 13910 of the Lactase Gene as a Risk Factor for the Formation of Insulin-Resistant Obesity in Children.

Aleksandr Abaturov,Anna Nikulina

doi:10.14712/18059694.2020.4

Abstract

To reduce the risk of insulin resistance in obesity in children with lactase gene genotypes, we studied the factors that stimulate the chronic inflammatory process. 109 children 6-18 years of age were investigated. The main group (n = 56) was presented by children with signs of insulin-resistant obesity according to the criteria of the European Society of Endocrinology and the Pediatric Endocrine Society. The control group (n = 53) included obese children without insulin resistance. A comprehensive clinical examination, food diary analysis, genotyping of the lactase gene by means of the polymerase chain reaction, the Immunochemical Test Method with Electrochemiluminescent Detection of basal insulinemia, Hydrogen breath test with lactose load, sequential analysis, ROC analysis were carried out. Clinical manifestations of lactose maldigestion in a child increased the risk of possible insulin resistance (prognostic coefficient (PC +2.6), as well as the presence of the lactase C/C 13910 gene genotype (PC +5.8) did. The genotype C/T 13910 in children had a protective effect on the risk of obesity (PC -2.9). The lowest risk of insulin-resistant obesity in observed among children with the genotype T/T 13910 (PC -12). The presence of the C/C 13910 genotype of the lactase gene is the main factor formation of insulin resistance in children's obesity. What is known? The genotype C/C 13910 of the lactase gene as a risk factor for the chronic inflammatory process in the body. What is New? Genotype C/C 13910 of the lactase gene as a risk factor for insulin-resistant obesity in children.

Highlights

To reduce the risk of insulin resistance in obesity in children with lactase gene genotypes, we studied the factors that stimulate the chronic inflammatory process
Risk factors for the formation of insulin resistance correlate most strongly among themselves in the group of examined children with the lactase gene (LCT) C/C 13910 genotype. In this group of examined patients, the presence of insulin-resistant obesity correlates with the level of systolic blood pressure (SBP) – ρ = 0.48 (p < 0.05), the ratio of the waist circumference to the hips (WC/HC) is ρ = 0.45 (p < 0.05)
The main risk factors for the development of pathological obesity in the early diagnostic stage are the genotype of the lactase C/C 13910 gene, basal hyperinsulinemia and the lack of daily consumption of up to 2–3 portions of fresh vegetables and fruits

Summary

Introduction

To reduce the risk of insulin resistance in obesity in children with lactase gene genotypes, we studied the factors that stimulate the chronic inflammatory process. Conclusion: The presence of the C/C 13910 genotype of the lactase gene is the main factor formation of insulin resistance in children’s obesity. The genotype C/C 13910 of the lactase gene as a risk factor for the chronic inflammatory process in the body. Genotype C/C 13910 of the lactase gene as a risk factor for insulin-resistant obesity in children. The discrepancy between the amount of lactose being consumed in the diet and the ability to secrete the lactase enzyme underlies the persistence of the chronic inflammatory process and the formation of obesity and insulin resistance. The average level of lactase activity in European children with the genotype C/C 13910 is 6.5 U/g (adult-type lactase deficiency, LD), while the activity of lactase with the C/T genotype is 29.9 U/g (heterozygous lactase persistence), and with genotype T/T 50 U/g (homozygous lactase persistence) [1].

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