Abstract
investigated the effects of cytidine deaminase (CDA)geneticpolymorphismsongemcitabinetoxicitiesandalteredpharma-cokinetics. They conclude, from the observation of a single Japanesepatientwiththenonsynonimousmutation208G A(Ala70Thr)anddisplaying an abnormal gemcitabine pharmacokinetic profile result-inginsubsequentneutropenia,thathaplotype*3harboringthe208GmorethanAsinglenucleotidepolymorphism(SNP)couldbeassoci-atedwiththeoccurrenceofseveretoxicitiesaftergemcitabineadmin-istration, and possibly, in combination with other chemotherapyregimens.Suchapatientwithseveretoxicitieswasactually,repeatedlyselectedoutofagroupoffive,
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