Abstract
Warfarin and clopidogrel are commonly used anticoagulant and antiplatelet drugs, and their response and/or toxicity were significant influenced by genetic polymorphism of drug metabolizing enzymes transporters and drug targets...
Highlights
Genetic polymorphisms of related enzymes were detected by fluorescence in situ hybridization (FISH)
Polymorphisms of cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase complex subunit 1 (VKORC1) genes are closely related to individualized treatment with warfarin [1]
Since CYP2C9*2 mutation is almost undetectable in Asian populations [2], we tested CYP2C9*3 (1075A>C, rs1057910) and VKORC1 (-1639G>A, rs9923231) for warfarin therapy
Summary
Han population and nonrelative, were inpatients or outpatients taking warfarin and/or clopidogrel at Qilu Hosiptal of Shandong University. Genetic polymorphisms of related enzymes were detected by fluorescence in situ hybridization (FISH). Polymorphisms of cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase complex subunit 1 (VKORC1) genes are closely related to individualized treatment with warfarin [1].
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