Abstract
The genotoxicity of the cyclopenta-fused polycyclic aromatic hydrocarbon, benz[ l]aceanthrylene (B[ l]A), was evaluated in vitro using the L5178Y TK + − mouse lymphoma assay and in vivo using the mouse peripheral blood lymphocyte (PBL) culture system. The mutagenicity and sister chromatid exchange (SCE) inducing potential of B[ l]A was then compared to that of benzo[ a]pyrene (B[ a]P). B[ l]A appeared to be slightly less mutagenic than B[ a]P at the TK locus, and each compound produced both small and large colony mutants indicating that they are clastogenic as well as mutagenic. Gross chromosome aberration analysis of treated L5178Y TK + − mouse lymphoma cells confirmed the clastogenicity of B[ l]A in vitro. In the mouse PBL system, after administration by gavage, B[ l]A was more cytotoxic and produced a sharper elevation in SCE frequency than B[ a]P.
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