Abstract
5-Methoxypsoralen (5-MOP) is used in cosmetic suntan preparations to stimulate the production of skin pigments. Although its isomer 8-methoxypsoralen (8-MOP) has been shown to be genotoxic in numerous biological systems, 5-MOP has not been so extensively investigated, but it has recently been reported to be mutagenic and carcinogenic. We have studied the lethal effects of 5-MOP and near ultraviolet light (NUV) on repair-deficient Escherichia coli strains. After treatment with 5-MOP at concentrations above 2 μ g/ml in combination with UV light survival of the repair-deficient strains was considerably reduced and strain WP100 uvrA − recA − was more sensitive than strain WP2 uvrA − . The effect was dependent on the time of irradiation and on the presence or absence of S-9 mix which inhibited the lethal activity of 5-MOP/NUV particularly when the NADP-generating system was included. These results support other indications that the use of 5-MOP in cosmetic preparations should be controlled.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
