Abstract
Schinopsis brasiliensis Engl. (Sapindales: Anacardiaceae) has been used in the Brazilian folk medicine to treat several illnesses. However, the phytochemical profile of S. brasiliensis as well as its genotoxic potential are poorly understood, which compromises population safety regarding the medicinal use of this plant species. In this study, we analyzed the genotoxic effects of S. brasiliensis using the Somatic Mutation and Recombination Test (SMART) of Drosophila melanogaster. Larvae from both standard cross (ST) and high bioactivation capacity cross (HB) were exposed to different concentrations of the hydroetanolic extract and ethyl acetate fraction of S. brasiliensis. We analyzed wings from D. melanogaster according to the type and number of mutant hair. Ours results suggested no genotoxic activity of S. brasiliensis in D. melanogaster somatic cells.
Highlights
Many plant species from Brazilian Caatinga have shown pharmacological potential, such as Erythrina velutina (Vasconcelos et al, 2007), Tabebuia aurea (Reis et al, 2014), and Ziziphus joazeir (Ribeiro et al, 2013)
This study aimed to evaluate the genotoxic effects of two extracts of S. brasiliensis on somatic cells of D. melanogaster by using the Somatic Mutation and Recombination Test (SMART)
Survivorship analysis of D. melanogaster revealed no cytotoxic potential of S. brasiliensis extracts on both standard cross (ST) and high bioactivation capacity cross (HB) cross flies
Summary
Many plant species from Brazilian Caatinga have shown pharmacological potential, such as Erythrina velutina (Vasconcelos et al, 2007), Tabebuia aurea (Reis et al, 2014), and Ziziphus joazeir (Ribeiro et al, 2013). When considering the number of native species from Caatinga that have been used by local communities, there are still few studies concerned with the composition and biological activity of most species (Vicentini et al, 2001; Liporacci et al, 2017). The genotoxic effects of medicinal plants are usually related to the concentration used by the individual (Corrêa et al, 2001; Sponchiado et al, 2016). Other aspects have to be considered when analyzing the genotoxic activity of plant species, such as the part of the plant, the age, and the presence of contaminants in the plant tissues (Saad et al, 2006). The popular commum names for this species include “baraúna”, “braúna”, and “quebracho” (Prado et al, 1995; Cardoso et al, 2015)
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