Abstract
Environmental burden with genotoxic chemicals is increasingly becoming a serious problem mainly due to hazardous waste dumping and industrial effluents. The Mutatox® mutagenicity assay was validated with known mutagen for its efficacy in the detection of direct mutagens and S-9 activated promutagens and applied to the complex environmental samples of landfill leachates from the Al-Sulaibiyah solid waste disposal site in Kuwait. The leachate samples from borehole 3 collected between December 1994 and May 1995 (cold and rainy months) showed genotoxic response in direct assay, indicating the presence of direct acting mutagens, whereas the samples collected between June and September 1995 (hot and dry months) were active in both direct and S-9 activated assay, also showing the presence of promutagens. Thus the leachate from the landfill, which is not equipped with a leachate collection and treatment facility, was found capable of exerting genotoxic effects that may influence the biota of the receiving system. © 1998 John Wiley & Sons, Inc. Environ Toxicol Water Qual 13: 127–131, 1998
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