Abstract
The cytotoxic effects of molybdocene dichloride (Cp 2MoCl 2) were investigated in V79 Chinese hamster lung cells using the micronucleus assay. Cp 2MoCl 2 produced significant genotoxic damage whereby 0.2 micronuclei/1000 binucleated cells were induced per μM of Cp 2MoCl 2. Transmission electron microscopic analysis of thin-sectioned cells treated with Cp 2MoCl 2 (300 μM) showed distinct morphological alterations of the nuclei, condensation of chromatin, and a high incidence of polynucleated cells. Implications for the mechanism of antitumor action of molybdocene dichloride are discussed.
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