Abstract
Neolignans are secondary metabolites found in various groups of Angiosperms. They belong to a class of natural compounds with great diversity of chemical structures and pharmacological activities. These compounds are formed by linking two phenylpropanoid units. Several compounds that have ability to prevent genetic damage have been isolated from plants, and can be used to prevent or delay the development of tumor cells. Genetic toxicology evaluation is widely used in risk assessment of new drugs in preclinical screening tests. In this study, we evaluated the genotoxicity and cytotoxicity of the neolignan analogue 2-(4-nitrophenoxy)-1-phenylethanone (4NF) and its protective effect against DNA damage using the mouse bone marrow micronucleus test and the comet assay in mouse peripheral blood. Our results showed that this neolignan analogue had no genotoxic activity and was able to reduce induced damage both in mouse bone marrow and peripheral blood. Although the neolignan analogue 4NF was cytotoxic, it reduced cyclophosphamide-induced cytotoxicity. In conclusion, it showed no genotoxic action, but exhibited cytotoxic, antigenotoxic, and anticytotoxic activities.
Highlights
Neolignans are secondary metabolites found in various groups of Angiosperms
Cytotoxicity was calculated by the ratio of polychromatic erythrocytes (PCE)/normochromatic erythrocytes (NCE)
The dose of 100 mg/kg was significantly different from the negative control group at 24 h of exposure (p < 0.05), demonstrating the cytotoxic action of the neolignan analogue 4NF at this dose
Summary
Neolignans are secondary metabolites found in various groups of Angiosperms. They belong to a class of natural compounds with great diversity of chemical structures and pharmacological activities. The oxyneolignan group exhibits a great variety of biological properties such as anti-leishmanial, antioxidant, and antitumor activities [2,3,4]. Among these compounds, 8-O-4' type neolignans are known to exhibit antifungal, antioxidant, anti-inflammatory, antitumor, and antinitric oxide production activities [4,5,6,7].
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