Abstract
<b>Objectives:</b> The present study was planned to explore the genotoxicity of morphine, buprenorphine, pentazocine, and noscapine.<br><b> Materials and Methods:</b> Bone marrow micronucleus assay and single cell gel electrophoresis assay were employed after 24 h (single dose) and 72 h (three doses) of treatment with clinically equivalent doses of opioids in albino mice. Percentage of micronucleated polychromatic erythrocytes and comet tail length were determined and the results were analyzed by one-way ANOVA and Student's 't' test.<br><b> Results:</b> Only morphine and noscapine showed significant (<i>P</i> < 0.01) increase in both the number of micronucleated polychromatic erythrocytes and comet tail lengths in acute (24-h) as well as subacute (72-h) studies.<br><b> Conclusions:</b> These results clearly indicate the genotoxic potential of morphine and noscapine at the clinically equivalent doses.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
