Genotoxic effects of bismuth (III) oxide nanoparticles by comet assay

Abstract

Event Abstract Back to Event Genotoxic effects of bismuth (III) oxide nanoparticles by comet assay Reecep Liman1*, Muhsin Konuk2 and İbrahim H. Ciğerci3 1 Uşak University, Molecular Biology and Genetics, Turkey 2 Üsküdar University, Molecular Biology and Genetics, Turkey 3 Afyon Kocatepe University, Molecular Biology and Genetics, Turkey Bismuth oxide is one of the important transition metal oxides and it has been intensively studied due to their peculiar characteristics (semiconductor band gap, high refractive index, high dielectric permittivity, high oxygen conductivity, resistivity, photoconductivity and photoluminescence etc.). Therefore, it is used such as microelectronics, sensor technology, optical coatings, transparent ceramic glass manufacturing, nanoenergetic gas generator, biosensor for DNA hybridization, potential immobilizing platforms for glucose oxidase and polyphenol oxidase, fuel cells, a additive in paints, an astringent in a variety of medical creams and topical ointments, and for the determination of heavy metal ions in drinking water, mineral water and urine. In addition this, Bismuth (III) oxide nanoparticles (BONPs) are favorable for the biomolecules adsorption than regular sized particles because of their greater advantages and novel characteristics (much higher specific surface, greater surface free energy, and good electrochemical stability etc.). Genotoxic effects of BONPs were investigated on the root cells of Allium cepa by Comet assay. A. cepa roots were treated with the aqueous dispersions of BONPs at 5 different concentrations (12.5, 25, 50, 75, and 100 ppm) for 4 h. A significant increase in DNA damage was also observed at all concentrations of BONPs except 12.5 ppm by Comet assay. The results were also analyzed statistically by using SPSS for Windows; Duncan’s multiple range test was performed. These result indicate that BONPs exhibit genotoxic activity in A. cepa root meristematic cells. Keywords: Allium, Comet, DNA Damage, bismuth oxide, Nanoparticles Conference: ICAW 2015 - 11th International Comet Assay Workshop, Antwerpen, Belgium, 1 Sep - 4 Sep, 2015. Presentation Type: Poster Presentation Topic: Genotoxicity testing of chemicals and nanomaterials Citation: Liman R, Konuk M and Ciğerci İH (2015). Genotoxic effects of bismuth (III) oxide nanoparticles by comet assay. Front. Genet. Conference Abstract: ICAW 2015 - 11th International Comet Assay Workshop. doi: 10.3389/conf.fgene.2015.01.00010 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 13 May 2015; Published Online: 23 Jun 2015. * Correspondence: Dr. Reecep Liman, Uşak University, Molecular Biology and Genetics, Uşak, Turkey, recep.liman@usak.edu.tr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Reecep Liman Muhsin Konuk İbrahim H Ciğerci Google Reecep Liman Muhsin Konuk İbrahim H Ciğerci Google Scholar Reecep Liman Muhsin Konuk İbrahim H Ciğerci PubMed Reecep Liman Muhsin Konuk İbrahim H Ciğerci Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.