Abstract
Exposure of human hepatoma Hep G2 cells for two hours to extractable organic matter (EOM) adsorbed on respirable airborne particles <10 μm (PM10) resulted in a linear dose-dependent increase in DNA damage (p < 0.001). There were clear locationand season-related differences in ambient air genotoxicity based on the amount of EOM associated with PM10 per unit volume of air (EOM μg/m). These data were correlated with the concentrations of benzo[a]pyrene, carcinogenic polycyclic aromatic hydrocarbons (PAHs) and total PAHs per cubic meter of air. No dose-dependent increase in the oxidative DNA damage (8-oxodG or M1dG adducts) was detected in EOM-exposed cells.
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