Abstract
The glial cell neoplasms are not fully classified by using cellular morphology. However, this is possible using known molecular markers in glial development. Oligo-dendrocyte lineage gene induces differentiation of neural progenitors and putative immature progenitor cells of the adult central nervous system. These oligo-dendrocyte lineage genes OLIG1 and OLIG2 encode basic helix-loop-helix transcription factors. The murine bHLH transcription factors found in chromosome 21 are essential for oligo-dendrocyte development. Moreover, OLIG3 of the OLIG family is known to be linked with the brain and spinal cord development. Therefore, it is of interest to analyse oligodendrocyte lineage genes in the OLIG family of bHLH domain for the understanding of oligo-dendrogenesis in eukaryotes. Several bHLH domain linked basic-helix-loop-helix transcription factors in Homo sapiens and Mus musculus from this analysis are reported. Thus, genomics data analysis of OLIG family of bHLH transcription factors help explain observed similarity and differences within the molecular evolutionary context and hence assess the functional significance of the distinct genetic blueprints
Highlights
The primary tumors of the human brain are thought to be glial cell origin
The glial cell neoplasm cannot be fully classified by cellular morphology or conventional markers for astrocyte or oligodendrocyte
The oligodendrocyte lineage transcription factors originally identified in rodent encoded bHLH transcription factors
Summary
The primary tumors of the human brain are thought to be glial cell origin. The glial cell neoplasm cannot be fully classified by cellular morphology or conventional markers for astrocyte or oligodendrocyte. The OLIG1 gene mapped to chromosome 21q22.11 base on sequence alignment in genomic data has roles in the development and maturation of oligodendrocytes especially within the brain. There are approximately 2600 proteins in the human genome containing DNA-binding domains with presumed function as transcription factors [27,28,29]. It is of interest to manually mine the literature for OLIG family of the bHLH transcription factor in Homo sapiens and Mus musculus with known heterogeneity of development and disease susceptibility of oligo dendrogenesis. HMMER is a statistical algorithm, making use of multiple sequence alignment (MSA) for specific domains in profile search It uses a factor in Homo sapiens and Mus musculus was completed. The transcription factor data analysis suggested 7 OLIG genes as well as 57, 58 bHLH domains in Homo sapiens and Mus musculus, respectively (Table 1). The genome wide analysis identified the genes OLIG1, OLIG2 and OLIG3 with conserved bHLH domain
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