Year-end Sale % OFF 
Abstract
With more and more Single Nucleotide Polymorphisms (SNPs) being identified throughout the genome, some of those SNPs will be found to be located within candidate genes, allowing the researchers to use the candidate gene approach on a genomewide scale. SNPs have some drawbacks but when compared to other markers they are more efficient and SNP consortium is growing to meet the requirements of genome-wide scans. Genomic selection should be able to at least double the rate of genetic gain in the dairy industry but the incorporation of genomic information into the breeding programs must be carefully considered. One needs to have around 2000 genotypes means a large reference population (population with both phenotype and genotype recorded) to achieve meaningful increases in accuracy. The available information, selection objectives, production circumstances and benefit/cost analysis must be evaluated in order to decide whether or not the population is suitable for GS implementation, and which would be the most convenient way, if any, for its implementation. Animal breeders will need to lead the way on the integration of genomic and phenotypic data into a new era of genome-enabled animal improvement and management.
Highlights
In the past century DNA has moved from being a mysterious molecule only of interest to a handful of specialists to being the heart of a technology that is transforming many aspects of the way we all live
In human population studies and subsequently in the major livestock species, attention has been switched to association-based studies harnessing the linkage disequilibrium across the population that can be found with dense marker panels
With more and more single nucleotide polymorphism (SNP) being identified throughout the genome, some of those SNPs will be found to be located within candidate genes, allowing the researchers to use the candidate gene approach on a genome-wide scale
Summary
In the past century DNA has moved from being a mysterious molecule only of interest to a handful of specialists to being the heart of a technology that is transforming many aspects of the way we all live. The study of human genetics has recently undergone a dramatic transition with the completion of both the sequencing of the human genome and the mapping of human haplotypes. In February 2001, two largely independent draft versions of the human genome were published. Both studies estimated that there are 30,000 to 40,000 genes in the human genome, roughly onethird the numbers of previous estimates. Since the completion of the human genome project, there has been a huge effort in establishing maps of genetic markers, especially of the most abundant source of DNA variation, the single nucleotide polymorphism (SNP). A subsequent major quest is to identify the variation in the human genome causally involved in the genetic etiology of complex diseases and drug response. Studies to explore which genes are involved in a trait include essentially two major approaches
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
