Abstract
Selecting the most appropriate mouse model that best recapitulates human hepatocellular carcinoma (HCC) allows translation of preclinical mouse studies into clinical studies. In the era of cancer genomics, comprehensive and integrative analysis of the human HCC genome has allowed categorization of HCC according to molecular subtypes. Despite the variety of mouse models that are available for preclinical research, there is a lack of evidence for mouse models that closely resemble human HCC. Therefore, it is necessary to identify the accurate mouse models that represent human HCC based on molecular subtype as well as histologic aggressiveness. In this review, we summarize the mouse models integrated with human HCC genomic data to provide information regarding the models that recapitulates the distinct aspect of HCC biology and prognosis based on molecular subtypes.
Highlights
Hepatocellular carcinoma (HCC) represents 75% of cases of primary liver cancer [1] and has worldwide prevalence of 841,000 cases per year, making it the sixth most common cancer globally, and 782,000 deaths occur annually [2]
In contrast to the general notion of ARID1A as a tumor suppressor, as demonstrated in the colon cancer model [56], deletion of Arid1a in mouse liver protected against development of hepatocellular carcinoma (HCC) [57], suggesting that Arid1a is necessary for the initiation of tumorigenesis in hepatocytes
Gene expression signatures reflecting the clinical and molecular study, we reported genomic data from nine mouse HCC models, integrated and analyzed together characteristics of tumors that are highly conserved in human and mouse tumors were reported with genomic data from human HCC to identify the mouse models that best resembled subtypes
Summary
Hepatocellular carcinoma (HCC) represents 75% of cases of primary liver cancer [1] and has worldwide prevalence of 841,000 cases per year, making it the sixth most common cancer globally, and 782,000 deaths occur annually [2]. Recent studies attempted to classify based on HCCthe arebiology progressing, and systematic of genomic data is providing insight HCC into the biology genetic, transcriptional, methylation, or miRNA levels [4,5]. HCC due to the physiological, molecular, and genetic similarities to basic humans, The laboratory is one of the most preferred experimental systems for both and the small size, large number of offspring, short lifespan, and low cost. The present article will review common types of mice that are used for different genomic signatures of human HCC to nine different HCC mouse models [15].
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