Abstract
Aims: Despite of intensive studies of glioblastoma multiforme , still no unified concept for the most important specific molecular alterations exists for this tumor type. The method of array CGH has great potential for molecular characterization of glioblastoma. The aim of our study was to determine the type, frequen cy and fine mapping of unbalanced genomic changes and to suggest candidate genes for the emergence and development of brain tumors. Study Design: Ten tumor samples were collected from patients with glioblastoma multiforme after taking informed consent. Hi stological examination was done to confirm the presence of tumor cells in more than 75% of the samples. DNA was isolated from each tumor sample. Place and Duration of Study: The material was collected in Department of Neurosurgery (Medical University Sofia) and processed for analysis in Department of
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