Abstract
Genetic selection for an increased growth rate in meat-type chickens has been accompanied by excessive fat accumulation particularly in abdominal cavity. These progressed to indirect and often unhealthy effects on meat quality properties and increased feed cost. Advances in genomics technology over recent years have led to the surprising discoveries that the genome is more complex than previously thought. Studies have identified multiple-genetic factors associated with abdominal fat deposition. Meanwhile, the obesity epidemic has focused attention on adipose tissue and the development of adipocytes. The aim of this review is to summarize the current understanding of genetic/epigenetic factors associated with abdominal fat deposition, or as it relates to the proliferation and differentiation of preadipocytes in chicken. The results discussed here have been identified by different genomic approaches, such as QTL-based studies, the candidate gene approach, epistatic interaction, copy number variation, single-nucleotide polymorphism screening, selection signature analysis, genome-wide association studies, RNA sequencing, and bisulfite sequencing. The studies mentioned in this review have described multiple-genetic factors involved in an abdominal fat deposition. Therefore, it is inevitable to further study the multiple-genetic factors in-depth to develop novel molecular markers or potential targets, which will provide promising applications for reducing abdominal fat deposition in meat-type chicken.
Highlights
Adipose tissue is an essential endocrine organ producing hormones and other substances that can deeply affect our health (Butterwith, 1997; Gregoire et al, 1998; Kershaw and Flier, 2004; Resnyk et al, 2015)
The purpose of this review paper is to summarize the current understanding of genetic/epigenetic factors associated with abdominal fat deposition, or as it relates to proliferation and differentiation of preadipocyte in chicken
Using deep sequencing, Wang et al (2015) identified 33 differentially expressed miRNA in preadipocyte isolated from abdominal adipose tissues of two broiler lines selected for abdominal fat content
Summary
Adipose tissue is an essential endocrine organ producing hormones and other substances that can deeply affect our health (Butterwith, 1997; Gregoire et al, 1998; Kershaw and Flier, 2004; Resnyk et al, 2015). Researchers have investigated the abdominal fat deposition in chicken using different genomic approaches, such as quantitative trait locus (QTL) analysis, the candidate gene approach, epistatic
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have