Abstract
Genomic imprinting is a kind of epigenetic mechanism,which affects monoallelic parent-oforigin-specific expression in mammal's development. Noncoding RNA( ncRNA) is a polynucleotides that does not code protein,it can regulate gene transcription. At least one non-coding RNA transcript is existed in most of the imprinted loci and genomic imprinting is mainly regulated by lang-non-coding RNA which the length is longer than 200 nt,through cis-transcriptional interference. Aberrant expression of imprinting gene and related lncRNA are the cause of some congenital diseases. So far,dozens of genetic imprinting is found to be related with human genetic diseases,in which genomic imprinting regulated by lncRNA plays an important role in the occurrence and treatment. The regulation disscussed mechanism of the genomic imprinting by lncRNA and its related diseases.
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