Abstract
606 Background: Genomic grade index (GGI) is a 97-gene signature which improves accuracy and prognostic value of histological grading (HG) in invasive breast carcinoma (IBC). GGI is particularly useful in segregating HG2 tumors into low or high Genomic Grade (GG1 and GG3). We aimed at prospectively evaluating the feasibility to implement GGI in routine practice with the primary objective of obtaining GGI in at least 80% of fresh tumor samples collected at surgery. Secondary objectives include GGI classification performance and impact on treatment recommendations. Methods: Eligible patients were pT1pT2 or operable pT3, N0-3 IBC. Fresh surgical samples with a H&E slide representative of the tumor specimen were sent at room temperature in the MapQuantKit for centralized analysis. Genomic profiles (Affymetrix U133 Plus 2.0) were determined for samples containing ≥ 30% invasive tumor cells and GGI calculated using the Ipsogen MapQuantDx protocol, which defines tumors as GG1 or GG3. Results: Between Jan and Dec...
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