Genomic features, phylogenetic relationships, and comparative genomics of Elizabethkingia anophelis strain EM361-97 isolated in Taiwan

Chih-Hui Yang,Yi-Han Huang,Jiun-Nong Lin,Hsi-Hsun Lin,Chung-Hsu Lai

doi:10.1038/s41598-017-14841-8

Chih-Hui Yang, Yi-Han Huang + Show 3 more

Open Access

https://doi.org/10.1038/s41598-017-14841-8

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Journal: Scientific Reports	Publication Date: Oct 30, 2017
Citations: 29	License type: open-access

Affiliation: Meiho University, I-Shou University, E-Da Hospital

Abstract

Elizabethkingia anophelis has become an emerging infection in humans. Recent research has shown that previous reports of E. meningoseptica infections might in fact be caused by E. anophelis. We aimed to investigate the genomic features, phylogenetic relationships, and comparative genomics of this emerging pathogen. Elizabethkingia anophelis strain EM361-97 was isolated from the blood of a cancer patient in Taiwan. The total length of the draft genome was 4,084,052 bp. The whole-genome analysis identified the presence of a number of antibiotic resistance genes, which corresponded with the antibiotic susceptibility phenotype of this strain. Based on the average nucleotide identity, the phylogenetic analysis revealed that E. anophelis EM361-97 was a sister group to E. anophelis FMS-007, which was isolated from a patient with T-cell non-Hodgkin’s lymphoma in China. Knowledge of the genomic characteristics and comparative genomics of E. anophelis will provide researchers and clinicians with important information to understand this emerging microorganism.

Highlights

Elizabethkingia anophelis has become an emerging infection in humans
Elizabethkingia is a genus of aerobic, nonfermenting, nonmotile, catalase-positive, oxidase-positive, indole-positive, and gram-negative bacilli that are usually distributed in soil and water environments[1,2,3]
This genus had rarely been responsible for infections in humans before

Summary

Introduction

Elizabethkingia anophelis has become an emerging infection in humans. Recent research has shown that previous reports of E. meningoseptica infections might be caused by E. anophelis. Elizabethkingia anophelis strain EM361-97 was isolated from the blood of a cancer patient in Taiwan. This genus had rarely been responsible for infections in humans before These microorganisms have been recently reported to cause life-threatening infections in immunocompromised patients, such as pneumonia, bacteraemia, meningitis, and neutropenic fever[1,2,3,4,5,6,7]. Among genus Elizabethkingia, E. meningoseptica, previously known as Chryseobacterium meningosepticum, is the most well-known species that causes opportunistic infection in humans[2,3].

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