Abstract
Comparative Yersinia genomics identifies features responsible for the colonization of specific host habitats and the horizontal transfer of virulence determinants.
Highlights
New DNA sequencing technologies have enabled detailed comparative genomic analyses of entire genera of bacterial pathogens
The most common sequencing error encountered when assembling pyrosequencing data is the rare calling of incorrect numbers of homopolymers caused by variation in the intensity of fluorescence emitted upon extension with the labeled nucleoside [34]
New Yersinia genome data reduce the pool of unique detection targets for Y. pestis and Y. enterocolitica The sequences generated in this study provide new background information for validating genus detection and diagnosis assays targeting pathogenic members of the Yersinia genus
Summary
New DNA sequencing technologies have enabled detailed comparative genomic analyses of entire genera of bacterial pathogens. Three species of the enterobacterial genus Yersinia that cause invasive human diseases (Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica) had been sequenced. There were no genomic data on the Yersinia species with more limited virulence potential, frequently found in soil and water environments. The first published sequencing studies on the Yersinia genus have focused exclusively on invasive human disease-causing species that included five Yersinia pestis genome sequences (one of which, strain 91001, is from the avirulent ‘microtus’ biovar) [9,10,11,12], two Yersinia pseudotuberculosis [13,14] and one Yersinia enterocolitica biotype 1B [15]. Like Y. pestis, the enteropathogenic Yersiniae can escape macrophages and multiply outside host cells, but unlike their more virulent cogener, they only usually cause self-limiting inflammatory diseases
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