Abstract
Salmonella enterica serovar Wangata is an important pathogen in New South Wales (NSW), Australia. The incidence of S. Wangata is increasing and transmission is suspected to be via a non-food source. A recent outbreak investigation of sources of S. Wangata recovered isolates from humans, domestic animals, wildlife and the environment. Here, we extend that investigation by characterising and describing the genomic determinates of these isolates. We found that Australian S. Wangata isolates from different sources exhibited similar virulence and antimicrobial resistance gene profiles. There were no major genomic differences between isolates obtained from different geographical regions within Australia or from different host species. In addition, we found evidence (low number of SNPs and identical virulence gene profiles) suggestive of an international transmission event between Australia and the United Kingdom. This study supports the hypothesis that S. Wangata is shared between different hosts in NSW, Australia and provides strong justification for the continued use of genomic surveillance of Salmonella.
Highlights
Salmonella enterica is a Gram-negative bacterium associated with a wide range of disease outcomes in humans, domestic animals and wildlife
Isolates were clustered by multi-locus sequence type (MLST) type, with all Australian isolates (ST523) clustering together
Using isolates obtained during the investigation of a slow moving outbreak and routine surveillance, we present the first genomic investigation of this serovar and describe its associated virulence and antimicrobial resistance (AMR) characteristics
Summary
Salmonella enterica is a Gram-negative bacterium associated with a wide range of disease outcomes in humans, domestic animals and wildlife. Salmonella infections vary from asymptomatic colonisation to gastroenteritis or severe, systemic disease [1, 2]. The disease outcome is determined by the pathogenicity and host specificity of the Salmonella serovar, as well as factors such as age and immune status of the infected host [2]. As with other enteric pathogens, Salmonella is capable of surviving in a range of different non-host environments [3, 4].
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