Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence

Stephan B Dreyer

doi:10.1053/j.gastro.2021.09.022

Abstract

Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence

Highlights

Pancreatic cancer (PC) remains a highly lethal malignancy, and most patients with localized disease that undergo surgical resection still succumb to recurrent disease
Recurrence patterns were classified as liver, lung, local only, and other distant, whereas the no recurrence group was defined as those that did not develop any recurrence during the study period.[3]
Transcriptomic, immunohistochemical, and clinical data of primary resected tumor specimens from the Australian Pancreatic Cancer Genome Initiative (Australian contribution to the International Cancer Genome Consortium) PC cohort were used in the molecular analysis (n 1⁄4 435)

Summary

Introduction

Pancreatic cancer (PC) remains a highly lethal malignancy, and most patients with localized disease that undergo surgical resection still succumb to recurrent disease. Recurrence patterns were classified as liver, lung, local only, and other distant, whereas the no recurrence group was defined as those that did not develop any recurrence during the study period (minimum of 24 months of follow-up).[3] Genomic, transcriptomic, immunohistochemical, and clinical data of primary resected tumor specimens from the Australian Pancreatic Cancer Genome Initiative (Australian contribution to the International Cancer Genome Consortium) PC cohort were used in the molecular analysis (n 1⁄4 435). Patients from the Australian Pancreatic Cancer Genome Initiative cohort were categorized based on transcriptional expression of the primary tumor as squamous (basal-like) or classical.[4] Squamous tumors correlated with liver recurrence and short disease-free survival after pancreatectomy (P < .001; Figure 1a, Supplementary Figure 1b).

Results

Conclusion