Abstract
Background: The synchronous primary right-sided and left-sided colon cancer (sRL-CC) is a peculiar subtype of colorectal cancer. However, the genomic landscape of sRL-CC remains elusive.Methods: Twenty-eight paired tumor samples and their corresponding normal mucosa samples from 14 patients were collected from the Second Affiliated Hospital of Harbin Medical University from 2011 to 2018. The clinical–pathological data were obtained, and whole-exome sequencing was performed based on formalin-fixed and paraffin-embedded samples of these patients, and then, comprehensive bioinformatic analyses were conducted.Results: Both the lesions of sRL-CC presented dissimilar histological grade and differentiation. Based on sequencing data, few overlapping SNV signatures, onco-driver gene mutations, and SMGs were identified. Moreover, the paired lesions harbored a different distribution of copy number variants (CNVs) and loss of heterozygosity. The clonal architecture analysis demonstrated the polyclonal origin of sRL-CC and inter-cancerous heterogeneity between two lesions.Conclusion: Our work provides evidence that lesions of sRL-CC share few overlapping mutational signatures and CNVs, and may originate from different clones.
Highlights
Synchronous multiple primary colorectal cancer (SM-CRC) refers to at least two primary lesions identified in a single patient
We collected 9,876 colorectal cancer patients, who were confirmed by pathological examination, in the Second Affiliated Hospital of Harbin Medical University from 2011 to 2018
67 were diagnosed with SM-CRC and 19 SMCRC patients were identified as sRL-CC
Summary
Synchronous multiple primary colorectal cancer (SM-CRC) refers to at least two primary lesions identified in a single patient. Synchronous primary right-sided and left-sided colon cancer (sRL-CC) is a peculiar subtype of SM-CRC. Previous studies have shown that genomic molecular aberration is a contributor to synchronous neoplasia (Ogino et al, 2006). The genomic landscape of sRLCC remains to be elucidated. Many works have shown that solitary left-sided colon cancer and right-sided colon cancer have different biological behaviors. Clinical studies revealed that patients with right colon. The synchronous primary right-sided and left-sided colon cancer (sRL-CC) is a peculiar subtype of colorectal cancer. The genomic landscape of sRL-CC remains elusive
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