Abstract
Objective: The median age of diagnosis for high-grade serous ovarian cancer (HGSOC) is 63 years, but HGSOC affects women of all ages. As a group, HGSOCs are characterized by recurrent TP53, BRCA1, and BRCA2 mutations and alterations in homologous recombination (HR) DNA repair. We sought to determine whether the mutational landscapes and genomic features of HR are distinct between older and younger HGSOC patients.
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