Abstract
The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses spaD-type and spaH-type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to understand their potential role in virulence characteristics.
Highlights
Nontoxigenic Corynebacterium diphtheriae strains have recently emerged as a major cause of invasive infections such as endocarditis, osteomyelitis and septic arthritis among patients [1,2,3]
The tox gene is present on lysogenizing corynephages which are absent from most nontoxigenic strains [5]
C. diphtheriae strain 5015 was cultured in 5 mL brain–heart infusion broth incubated at 37°C for 16 hours in a shaking incubator
Summary
Nontoxigenic Corynebacterium diphtheriae strains have recently emerged as a major cause of invasive infections such as endocarditis, osteomyelitis and septic arthritis among patients [1,2,3]. The tox gene is present on lysogenizing corynephages which are absent from most nontoxigenic strains [5]. The annotated genome sequence of C. diphtheriae strain 5015 has been submitted to the DNA Data Bank of Japan, European Molecular Biology Laboratory, and GenBank databases and is publicly available under accession number MSIS00000000.
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