Abstract
Enteric infections caused by Salmonella spp. represent a major public health problem worldwide, due to the large proportion of foodborne infections derived from this pathogen. Currently, antimicrobials are used to prevent contamination of chicken meat. However, in order to combat salmonellosis without the propagation of resistant strains, it is necessary to study alternative therapeutic approaches, such as the use of bacteriophages against Salmonellosis. For the present work bacteriophages provided by FMRP-USP were selected to further studies on its therapeutic potential. In addition, we work with lytic bacteriophages induced from monophasic strains of Salmonella spp. Our initial aim for this project was the morphological and molecular characterization of these viruses. Nevertheless, the environmental phages did not survive the storage period. Due to these results, our further studies will be focused on the lytic phages. They will be tested in vivo in the C. elegans model in order to evaluate the survival rate of the worms when infected with Salmonella spp.
Highlights
One of the most common foodborne diseases is salmonellosis, an infection caused by Salmonella spp. a genus of bacteria
We have studied phages isolate from chicken farms and induced phages of monophasic Salmonella spp
9 bacteriophages were selected from a previous research conducted at FMRP-USP
Summary
One of the most common foodborne diseases is salmonellosis, an infection caused by Salmonella spp. a genus of bacteria. This infection affects humans and jeopardizes the poultry industry. Due to the high demand for poultry products worldwide, use of antimicrobials as growth promoters in chicken has been a common practice. With the increasing number of resistant bacteria, it is necessary to invest in alternatives therapies to avoid foodborne pathogens. One of the solutions can be the use of bacteriophages therapy. Bacteriophages are viruses that infect and lyse bacterial cells.
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