Abstract
During growth, oocytes acquire highly specialized chromatin modifications including DNA methylation and histone acetylation. These genome-wide epigenetic changes are essential for the establishment of parent-specific marks on imprinted genes. Scientists in the assisted reproductive technologies (ART) are increasingly utilizing immature germ cells in gamete research; as well as in clinical settings, such as in-vitro studies of growth/maturation of oocytes from cryopreserved ovarian tissue, for potential infertility treatments.
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