Abstract
Genome‐wide <scp>DNA</scp> methylation profiling predicts relapse in childhood B‐cell acute lymphoblastic leukaemia
Highlights
We identified 3,414 Differentially methylated CpG site (dmCpG), 88Á2% (3,014) and 11Á8% (400) of which respectively lost and gained DNA methylation in cancer samples (Fig 1D; Fig S2)
We suggest that defects in the B-cell differentiation process display a unique property of samples present in acute lymphoblastic leukaemia (ALL)-2
The gene ontology (GO) and Polycomb target genes (PcTG) analyses suggest that hypomethylation of genes involved in developmental processes are a unique feature of patient samples present in ALL-2
Summary
M., Bucchioni, S., Galbusera, M., Donadelli, R., Bresin, E., Castelletti, F., Caprioli, J., Brioschi, S., Scheiflinger, F. (2004) Functional analysis in serum from atypical Hemolytic Uremic Syndrome patients reveals impaired protection of host cells associated with mutations in factor H. Genome-wide DNA methylation profiling predicts relapse in childhood B-cell acute lymphoblastic leukaemia
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