Abstract
Breeding of genetically resistant chickens to Marek’s disease (MD) is a vital strategy to poultry health. To find the markers underlying the genetic resistance to MD, copy number variation (CNV) was examined in inbred MD-resistant and -susceptible chicken lines. A total of 45 CNVs were found in four lines of chickens, and 28 were potentially involved in immune response and cell proliferation, etc. Importantly, two CNVs related with MD resistance were transmitted to descendent recombinant congenic lines that differ in susceptibility to MD. Our findings may lead to better strategies for genetic improvement of disease resistance in poultry.
Highlights
Breeding of genetically resistant chickens to Marek’s disease (MD) is a vital strategy to poultry health
Identification of copy number variation (CNV) in chickens with different susceptibility to MD By using the accepted criteria of 0.5_5 to identify CNVs, we identified a total of 72 CNVs (Table S2) in four chicken lines
In this study, we studied the CNVs in inbred chicken lines with different susceptibility to MD by array comparative genomic hybridization CGH (aCGH)
Summary
Breeding of genetically resistant chickens to Marek’s disease (MD) is a vital strategy to poultry health. Genetic and genomic variations potentially underlying the varied susceptibility to MD in these lines of chickens remain poorly understood. Using two highly inbred lines of White Leghorn and two RCSs of the two inbred lines, which vary in resistance/susceptibility to MD, we performed an array comparative genomic hybridization CGH (aCGH) analysis of the four lines of chickens to test our hypothesis. To this end, we identified 45 CNVs in total by comparison among the four lines of chickens. We compared our CNVs with the MD-related quantitative trait loci (QTL) regions
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