Abstract
Ovine progressive pneumonia virus (OPPV) is an important virus that causes serious diseases in sheep and goats with a prevalence of 36% in the USA. Although OPPV was discovered more than half of a century ago, little is known about the infection and pathogenesis of this virus. In this report, we used RNA-seq technology to conduct a genome-wide probe for cellular factors that are associated with OPPV infection. A total of approximately 22,000 goat host genes were detected of which 657 were found to have been significantly up-regulated and 889 down-regulated at 12 hours post-infection. In addition to previously known restriction factors from other viral infections, a number of factors which may be specific for OPPV infection were uncovered. The data from this RNA-seq study will be helpful in our understanding of OPPV infection, and also for further study in the prevention and intervention of this viral disease.
Highlights
Ovine progressive pneumonia virus (OPPV), or visna/maedi virus (VMV) in sheep [1,2,3], and caprine arthritis encephalitis virus (CAEV) in goats [4,5,6], all belong to one viral species called small ruminant lentiviruses (SRLV) according to current viral classifications [7]
During OPPV infection, the host responds to the infection and launches anti-viral defenses from both the innate and adaptive arms of the immune system
Our results indicate that OPPV infection dynamics peak at 12h p.i., and are reduced about one half by 24h p.i., remaining constant until 48h p.i. (Fig 1)
Summary
Ovine progressive pneumonia virus (OPPV), or visna/maedi virus (VMV) in sheep [1,2,3], and caprine arthritis encephalitis virus (CAEV) in goats [4,5,6], all belong to one viral species called small ruminant lentiviruses (SRLV) according to current viral classifications [7]. These viruses are genetically very similar, with some OPPV strains being more closely related to CAEV than to other OPPV strains [7]. Subtype classification of SRLV has been applied based on viral genetic
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