Abstract
Background The acquisition of somatic alterations (point mutations/ chromosomal rearrangements) underlies the hallmarks of cancer, generating genetic diversity that drives tumorigenesis. Advances in the study of cancer genomes revealed in solid tumors a complex pattern of copy number alterations (CNA), structural rearrangements, and aneuplodies. Breast cancer (BC) is the most common malignancy in females, being the leading cause of death by cancer. This heterogeneous disease is not fully understood yet; however, genomic studies have identified unique CNA patterns in different BC subtypes. Regarding the subtype triple-negative (TN; estrogen and progesterone receptors, and HER2 negative expression levels), only limited data are available on which genes or chromosome regions are involved in its initiation and progression.
Highlights
The acquisition of somatic alterations underlies the hallmarks of cancer, generating genetic diversity that drives tumorigenesis
Advances in the study of cancer genomes revealed in solid tumors a complex pattern of copy number alterations (CNA), structural rearrangements, and aneuplodies
Regarding the subtype triple-negative (TN; estrogen and progesterone receptors, and HER2 negative expression levels), only limited data are available on which genes or chromosome regions are involved in its initiation and progression
Summary
Felipe Fidalgo1*, Amanda Gonçalves[1], Tatiane Rodrigues[2], Alex Fiorini[1], Dirce Maria Carraro[1], Carla Rosenberg[2], Ana Cristina Victorino Krepischi[1]. From São Paulo Advanced School of Comparative Oncology Águas de São Pedro, Brazil. From São Paulo Advanced School of Comparative Oncology Águas de São Pedro, Brazil. 30 September - 6 October 2012
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
