Abstract
We combined the results of whole-genome linkage and association analyses to determine which markers were most strongly associated with Kofendrerd Personality Disorder. Using replicate 1 from the Genetic Analysis Workshop 14 Aipotu, Karangar, Danacaa, and New York City simulated populations, we determined that several markers showed significant linkage and association with disease status. We used both SNP and microsatellite markers to determine patterns and chromosomal regions of markers. Three consistently associated markers were C01R0050, C03R0280, and C10R0882. Using generalized linear mixed models, we modelled the effect of the three predefined phenotypic categories on disease status and concluded that the phenotypes defining the "anxiety-related" category best predicted the outcome.
Highlights
Whole-genome linkage analyses involve looking for coinheritance of chromosomal regions with disease in families
The aim of this contribution was to perform linkage analyses, in combination with association analyses, on replicate 1 of the simulated Genetic Analysis Workshop 14 (GAW14) data to determine which markers or regions of markers are associated with Kofendrerd Personality Disorder (KPD)
We proceeded to select regions that appeared to be of most significance for linkage and/or association
Summary
Whole-genome linkage analyses involve looking for coinheritance of chromosomal regions with disease in families. Family-based association studies utilize the available pedigree genetic variations to determine whether the transmission of particular genetic variants is associated with disease status. The results of linkage and association studies have been successfully combined in many analyses to refine the location of disease genes and to test the involvement of candidate genes in disease. The aim of this contribution was to perform linkage analyses, in combination with association analyses, on replicate 1 of the simulated Genetic Analysis Workshop 14 (GAW14) data to determine which markers or regions of markers are associated with Kofendrerd Personality Disorder (KPD)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
