Abstract
Heat shock proteins 70 (Hsp70) are required for key cellular processes and responses to environmental changes, however, there are an unknown number of hsp70 gene family members in the large yellow croaker (Larimichthys crocea). In the present study, 17 hsp70 genes were identified through the genome of the large yellow croaker. These genes are divided into seven evolutionarily distinct groups according to a phylogenetic tree. The orthologs of these hsp70 genes were found in humans and zebrafish. The expression patterns of the hsp70 gene family in the large yellow croaker under cold and heat stress were studied by examining transcriptome data. Six out of 17 genes were significantly unregulated or downregulated after cold or heat stress. There were two genes significantly upregulated and two genes downregulated in the liver after cold treatment, while after heat treatment, five genes were significantly upregulated, and no genes were significantly downregulated. Three expression patterns were detected: strictly heat-inducible hsp70, constitutively expressed and moderately heat-inducible hsp70, and constitutively expressed and less stress-dependent hsp70 genes. All the findings will contribute to a better understanding of the biological function of hsp70s in defending against thermal challenges.
Highlights
Heat shock proteins (Hsps) are a large group of molecular chaperones
We obtained a total of 17 members representing the unique hsp70 gene family in the large yellow croaker and created robust nomenclature following the Zebrafish Nomenclature
Regulated expression of one hsp70 gene under thermal stress has been reported in the regulated expression of one hsp70 gene under thermal stress has been reported in the large yellow croaker [16], a systematic analysis of hsp70 involvement in response to thermal stress had large yellow croaker [16], a systematic analysis of hsp70 involvement in response to thermal stress not been conducted in this species
Summary
Heat shock proteins (Hsps) are a large group of molecular chaperones. They are produced by cells in response to high temperature, hypoxia, infection, toxins, and a number of other types of stress.Some Hsps genes are named housekeeping proteins with constitutively expressed in non-stressed cells [1]. Heat shock proteins (Hsps) are a large group of molecular chaperones. They are produced by cells in response to high temperature, hypoxia, infection, toxins, and a number of other types of stress. Some Hsps genes are named housekeeping proteins with constitutively expressed in non-stressed cells [1]. Hsp110, Hsp, Hsp, Hsp, Hsp, Hsp, and small Hsps, are classified by their molecular weight [3]. The hsp gene family is an important member of the Hsps superfamily, as it is widely distributed in all organisms from bacteria to mammals, except for some archaea [4,5,6]
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