Genome-wide association of longitudinal volumetric mri measurements in the Alzheimer's Disease Neuroimaging Initiative (ADNI) study

Abstract

type 2 diabetes onMay 2008 to January 2009 at the TianjinMedical University hospital metabolic diseases. Select 40 cases of type 2 diabetes with MCI,80 cases of type 2 diabetes without MCI. The diagnosis of type 2 diabetes is according to the diagnostic criteria of WHO in 1999. The comprehensive assessment of cognitive function is carried out to each of those subjects using mini-mental state examination (MMSE), clock drawing test (CDT). The polymorphism of the Apo E genewas detected by PCR-Restriction Fragment Length Polymorphism (PCR-RFLP). According to the clinical data such as age, course of disease, family history of diabetes, plasma glucose, plasma fat and body mass index (BMI), hypertension, diabetic retinopathy, diabetic peripheral neuropathy, diabetic nephropathy, coronary heart disease and insulin therapy, analyze the impact of Apo E allele in the pathogenesis of T2DM and MCI and the independent risk factors of T2DM and MCI by non-conditional logistic regression. Results: The frequency of Apo E e4 allele in the group of type 2 diabetes with MCI was higher than that without MCI, and the difference had statistical significance (P < 0.01). The indexes of the statistical significant difference between the two groups are age, course of disease, postprandial blood glucose (P2BG), HBA1C, BMI, family history of T2DM, Hypertension, Diabetic Retinopathy, Diabetic Peripheral Neuropathy, Apo E gene. The independent risk factors included Diabetic Retinopathy, Diabetic Peripheral Neuropathy, Apo E gene (OR 1⁄4 4.25, P 1⁄4 0.014), HBA1C, P2BG, age and course of disease. Conclusions: Apo E e4 allele has significant relationship with T2DM and MCI. The age, course of disease, control of plasma glucose and Microvascular Complication of diabetes have relationship with the cognitive function. So the emphasis on early and effective treatment of the T2DM patients may play an important role in the prevention of dementia.