Abstract
Vertebrate genomes contain GC-rich or poor compartments, called isochores, It has been reported that heavy isochores (GC-rich) contain housekeeping genes while light ischores (GC-rich) have tissuespecific genes [1]. On the other hand, it was mentioned oppositely that there was no correlation between GC contents and tissue specificity [4, 5]. One of the major reasons for this conflicting idea is probably caused by the inaccurate information of transcription start site (TSS) in each gene. Recently, we constructed DBTSS: DataBase of Transcription Start Sites [6]. In this database, the clones which were constructed by the oligo-capping method show TSSs of a gene with high accuracy. Here we used data in DBTSS to determine precise TSSs and studied correlation between CpG islands and tissue-specificity using them.
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