Abstract
Background: Osteosarcoma is a primary malignant bone tumor commonly found in children and young adults. The prognosis of patients with metastatic osteosarcoma is very poor. Different studies have shown that immune infiltration is associated with osteosarcoma metastasis. However, the cellular composition of immune infiltrates may vary slightly in osteosarcoma metastases. Recent studies have reported that abnormal alternative splicing regulation is related to the occurrence and development of cancer.
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