Abstract
Transcriptional Enhancers play a crucial role in spatiotemporal expression of genes. Dysregulation of enhancers, due to mutations in transcription factors and chromatin regulators, has emerged as a major cause of human cancer. A thorough understanding of cell type specificity, function and mechanisms of action of enhancers will be valuable for development of new diagnostics and therapeutics targeting cancers. I will present our latest advances in identification and characterization of enhancers in the human and mouse genomes, across multiple stages of development, in normal and disease states, and often in single cell resolution. In addition, I will present progress in mapping distal enhancers to their target genes, via analysis of the 3‐dimensional genome architecture and chromatin loops, in order to access the role of non‐coding variants in human diseases. Finally, I will present results from large‐scale functional screenings of oncogenic enhancers in cancer cells.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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